IISER Mohali, Knowledge city, Sector 81, SAS Nagar, Manauli PO 140306

A step towards predicting the immune response

Dr. Koushik Roy, Institute for Quantitative and Computational Biosciences, University of California, Los Angeles

Location Academic Block-II AB2-5A
Rapid antibody production in response to invading pathogens requires a dramatic expansion of antigen-specific B cells followed by differentiation into plasma cells. Utilizing iterative systems biology approach, we revealed deterministic B cell fate decision and discovered a new regulatory network (mutual antagonism of cRel and Blimp1) of plasma cell differentiation. Multi-scale modeling showed how coordinated dynamics of transcription factor control B cell populations dynamics in health and disease.
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