IISER Mohali, Knowledge city, Sector 81, SAS Nagar, Manauli PO 140306

Dr. Samrat Mukhopadhyay
Associate Professor, Biological Sciences & Chemical Sciences

Email mukhopadhyay(AT)iisermohali.ac.in
Phone +91 172 2293
Fax +91 172 2240266
Personal Page The Mukhopadhyay Research Group

Research Area: 

Intrinsically Disordered Proteins, Protein Misfolding, Prions and Amyloids

Research Focus

Proteins are the workhorses of the living systems. For carrying out specific functions, proteins have to fold up correctly. Incorrect folding or protein misfolding can lead to amyloid aggregation and is implicated in a number of neurological disorders such as Alzheimer's, Parkinson and prion diseases. The molecular mechanisms of protein folding, misfolding, aggregation and amyloid fibril formation are poorly understood. Our laboratory is actively involved in unraveling the molecular mechanism of aggregation of a diverse class of proteins using modern fluorescence spectroscopy in combination with other state-of-the-art biophysical tools including single-molecule spectroscopy and nanoscale imaging. Using a diverse array of biophysical techniques, combined with modern cellular and molecular biology tools, we have embarked upon studies aimed at detecting and characterizing the oligomeric intermediates that serve as precursors to ordered amyloid fibrils. The oligomeric species are of particular interest since they are proposed to be the key toxic agents involved in neurodegeneration. We are also interested in devising chemical biology approach to develop small-molecule drugs that can inhibit protein aggregation. Our interdisciplinary efforts involve techniques and concepts of biology, chemistry and physics.

Selected Publications
  • "pH-Responsive Mechanistic Switch Regulates the Formation of Dendritic and Fibrillar Nanostructures of a Functional Amyloid" P. Dogra, M. Bhattacharya & S. Mukhopadhyay (2017) J. Phys. Chem. B. 121, 412-419.
  • "Water Rearrangements upon Disorder-to-Order Amyloid Transition" S. Arya, A. K. Singh, T. Khan, M. Bhattacharya, A. Datta, & S. Mukhopadhyay (2016) J. Phys. Chem. Lett. 7, 4105-4110.
  • "Direct Observation of the Intrinsic Backbone Torsional Mobility of Disordered Proteins" N. Jain, D. Narang, K. Bhasne, V. Dalal, S. Arya, M. Bhattacharya, & S. Mukhopadhyay (2016) Biophys. J. 111, 768-774. (Featured in Faculty of 1000: http://f1000.com/prime/726673346)
  • "Confined Water in Amyloid-Competent Oligomers of the Prion Protein" V.Dalal, S. Arya, & S.Mukhopadhyay (2016) ChemPhysChem 17, 2804-2807.
  • "Conformational Switching and Nanoscale Assembly of Human Prion Protein into Polymorphic Amyloids via Structurally-Labile Oligomers" V. Dalal, S. Arya, M. Bhattacharya & S. Mukhopadhyay (2015) Biochemistry 54, 7505-7513.


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