Solid-state nuclear magnetic resonance (SSNMR) is the application of NMR spectroscopy to systems that are solids, nearly solids, or strongly anisotropic. Recent advancements in this field have established solid-state NMR as a viable alternative for determining the structure of biological systems (membrane proteins and peptide aggregates) that are less amenable to characterization by other high-resolution techniques. In spite of the tremendous progress made in the last decade or so, SSNMR is still a developing field and methods towards structural characterization are just emerging.
The primary objectives of our research group are to invoke the principles of physics and try to apply them in solving problems in chemistry and structural biology. In this regard we plan to use Solid-state Nuclear Magnetic Resonance (SSNMR) spectroscopy as a tool to understand the biological implications of structural transformations taking place in proteins and their role in protein related diseases.
Besides its implications in chemistry and structural biology, SSNMR can also be used as a test-bed to investigate/understand some of the founding principles of quantum physics.
- Effective Hamiltonians in Floquet theory of magic angle spinning using van Vleck transformation, R. Ramesh and Mangala Sunder Krishnan, Journal of Chemical Physics, v-114, p-5967 (2001).
- 13C-13C Rotational Resonance width distance measurements in uniformly 13C-labeld peptides, Ramesh Ramachandran,Vladimir Ladizhansky, Vikram S. Bajaj and Robert G. Griffin, Journal of American Chemical Society,v-125, p-15623 (2003)
- Multipole-multimode Floquet theory in nuclear magnetic resonance, Ramesh Ramachandran and Robert G. Griffin, Journal of Chemical Physicsv-122, p-164502 (2005) .
- Description of depolarization effects in double-quantum solid-state nuclear magnetic resonance experiments using MMFT, Ramesh Ramachandran and Robert G. Griffin,Journal of Chemical Physics, v-125, p-044510 (2006).
- Radio frequency-driven recoupling at high magic angle spinning frequencies: Homonuclear recoupling sans heteronuclear decoupling, Marvin J. Bayro, Ramesh Ramachandran, Marc A. Caporini, Matthew T. Eddy and Robert G Griffin, Journal of Chemical Physics, v-128, p-052321 (2008).