|INDIAN INSTITUTE OF SCIENCE EDUCATION & RESEARCH, MOHALI|
Associate Professor (Biology)
Knowledge city, Sector 81, SAS Nagar,
Manauli PO 140306
Web: My webpage
Research Area I: Structure-Function Studies on Pore-Forming Protein Toxins.
Pore-forming protein toxins (PFTs) represent a special class of membrane damaging cytolytic proteins, and they are found in wide spectrum of organisms ranging from bacteria to humans. They exert their toxic effects by punching 'holes' into target cell membrane, thus destroying the natural permeability barrier function of the cell membrane. PFTs are, in general, synthesized as water-soluble monomeric molecules, and in contact with target cell membranes they form membrane-inserted oligomeric pores. However, in spite of sharing this overall general scheme, PFTs differ significantly from each other in the intricate details of their pore formation mechanisms. A major mechanistic challenge associated with the membrane pore formation process by PFTs is elucidating the folding pathways that ensure thermodynamic compatibility of the water-soluble monomeric and the membrane-inserted oligomeric form of the toxin with aqueous and lipid milieu, respectively. One of the major research interests of my group is focused on studying structure-function relationship of some of the prominent bacterial PFTs. The critical issues we address are:
An optimal T cell immune response depends critically on costimulatory signals triggered by a wide array of receptor-ligand interactions at the interface of T cells and antigen presenting cells. A balance between positive and negative T cell costimulatory signals is extremely crucial in terms of generating an optimal protective immune response, while at the same time maintaining a state of immunological tolerance. Activation of T cell costimulatory pathway, in general, follows a common paradigm in which interaction between the extracellular domains of the costimulatory receptors and their cognate ligands triggers the intracellular signaling cascades. Understanding the structural basis of costimulatory interactions is central toward developing therapeutic strategies to manipulate T cell-mediated immune responses in various disease conditions. We explore the critical structural features involved in the costimulatory interactions, and plan to utilize our structure-based knowledge to develop therapeutic strategies targeting T cell immunity.
For complete publication list please visit:http://sites.google.com/site/kausikchattopadhyaysite/publications