|INDIAN INSTITUTE OF SCIENCE EDUCATION & RESEARCH, MOHALI|
Knowledge city, Sector 81, SAS Nagar,
Manauli PO 140306
Email: guptasarma[at]iisermohali.ac.in, guptasarma[at]yahoo.com
INTERESTS: My main interests lie in understanding and engineering the manner in which globular proteins fold; in why (and how) they misfold; in what these misfolded forms do (to cause human disease) or can be made to do (e.g., conduct electricity); in what determines the thermodynamic and kinetic stabilities of the folded, native forms of globular proteins (especially those evolved to function in extremophile microbes); and in developing approaches through which the activities and functions of globular proteins and enzymes can be altered through rational and/or combinatorial mutagenesis.
APPROACHES: I commonly employ (and also occasionally develop) preparative and analytical methods/approaches deriving from different forms of electronic and vibrational spectroscopy, mass spectrometry, biomolecular chromatography, electrophoresis, computation, calorimetry, microscopy, and recombinant DNA-based experimentation, and also certain other tools/techniques of organic and physical biochemistry.
ET CETERA: In addition, I also love to dwell upon (and occasionally contribute to) current understanding of the mechanistic basis of regulation of gene expression, and the cellular and molecular basis of development.