INDIAN INSTITUTE OF SCIENCE EDUCATION & RESEARCH, MOHALI
   Dr. Sharvan Sehrawat

   Assistant Professor (Biology)
   Knowledge city, Sector 81, SAS Nagar,
   Manauli PO 140306

   Email: sharvan[at]iisermohali.ac.in
   Web: Dr. Sehrawat's Lab at IISER Mohali
   Telefax: +91-172-2240266
   Mob: +91 9780111944

Research Area: Immunology and immunopathology

Induction of an adaptive immune response and its maintenance in the memory phase forms the basis of lasting protective immunity against infectious diseases and provides clue for successful vaccination. After receiving help from CD4 T cells, pathogen-specific CD8 T cells are appropriately activated to control the spread of intracellular pathogens such as viruses. Animal models are used to investigate host-pathogen interaction. For studying the function and differentiation of adaptive T and B cells, one has to secure sufficient number of antigen-specific cells in naive state but in a normal host the frequency of T cells specific to any given antigen is very low and frustrates attempts at isolating such cells in meaningful numbers. In our laboratory we aim to understand the function and differentiation of CD8 T cells during infection with endemic pathogens such as dengue virus, Chikungunya virus and protozoan parasites such as Plasmodium in addition to herpes viruses, the latter being the most successful pathogen. Employing various molecular and immunological approaches, we try to understand the host-pathogen interaction. We are also putting efforts in developing novel animal models to study immunity and immunopathology during viral infections. We welcome creative colleagues who are interested in learning and contributing to the advancement of immunology to join our group.

Selected Publications

  • Veiga-Parga T, Sehrawat S and Rouse BT (2013) Regulatory T cell function in anti-viral immunity. Immunol Reviews 255(1):182-96
  • Sehrawat S, Koenig, PA, Kirak O, Schlieker C and Ploegh HL (2013) A catalytically inactive mutant of deubiquitylase YOD-1 enhances the antigen cross presentation. Blood 121(7):1145-56
  • Sehrawat S, Kirak O, Koenig PA, Issacson MK, Marques S, Bozkurt G, Simas JP, Jaenisch R and Ploegh HL (2012). CD8+ T cells from mice transnuclear for a TCR that recognizes a single H-2Kb-restricted MHV68 epitope derived from gB (ORF8) help control the infection. Cell rep 1:461-471.
  • Sehrawat S* and Rouse BT (2011) Tregs and Infections: On the potential value of modifying their function? J Leukoc Biol. 90: 1079-1087.
  • Rouse BT and Sehrawat S (2010) Immunity and immunopathology to viruses: What decides the outcome? Nature Rev Immunology 10, 514-526.

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