Associate Professor
Department of Biological Sciences
📍 1F10 AB1
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Research Area
Immunology and Immunopathology
Research Interests
The focus of research in Dr Sehrawat’s lab is investigating immunity and immunopathology to infectious agents. His laboratory has generated therapeutic single domain antibodies or nanobodies for managing public health problems such as snake bites, infection of viruses (dengue virus, corona virus), antimicrobial resistant (AMR) bacteria such as methicillin resistant Staphylococuss aureus (MRSA), pathogenic E. coli using an in-house constructed phage display library. They have then extensively characterised and modified these antibodies to enhance their therapeutic value by generating bivalent and bispecific antibodies. Such products showed promising value in blocking infection and improving the outcome of disease when tested in animal model/s. Given the future need to manage health problems in the aging population, his group has discovered Rab8a, a small GTPase, as a novel key regulator of dysfunctional dendritic cells (DCs) of the aging host. Furthermore, they have demonstrated that a genetic reconstitution of aged DCs with Rab8a enhanced their lost functions and promoted anti-viral immunity. Such an approach would also be valuable for achieving favourable outcome of malignancies using cell based therapies. They have also demonstrated the utility of several approaches which promoted the response of virus-specific memory cytotoxic T lymphocytes, a desirable outcome of vaccination.
Since 2020 : Associate Professor, Indian Institute of Science Education and Research Mohali 140306
2013 - 2020 : Assistant Professor, Indian Institute of Science Education and Research Mohali Mohali 140306
Apr 2013 - Nov 2013 : Scientist C, Infectious Disease Biology, Institute of Life Sciences Department of Biotechnology, Govt of India, Bhubaneswar 751023
Oct 2009 - Mar 2013 : Post-doctoral Fellow , Whitehead Institute for Biomedical Research (Massachusetts Institute of Technology), Cambridge, MA, USA
Dec 2008 - Oct 2009 : Post-doctoral Research Associate, Dept of Pathobiology, The University of Tennessee, Knoxville, TN, USA
Aug 2005 - Dec 2008 : Doctor of Philosophy (Ph.D) in Comparative and Experimental Medicine, University of Tennessee, Knoxville, TN, USA
Feb 2002 - Apr 2004 : Master of Veterinary Science (M.V.Sc.) in Veterinary Immunology CCS Haryana Agricultural University, Hisar, India
Aug 1996 - Oct 2001 : Bachelor of Veterinary Science and Animal Husbandry (B.V.Sc and A.H.) CCS Haryana Agricultural University, Hisar, India
Charles King Trust Fellowship to pursue Post-doctoral Research at Whitehead Institute for Biomedical Research (MIT) Cambridge, MA USA June 2013 (Not availed).
Oakridge National Laboratory distinguished Staff fellowship March 2013 (Not availed)
Landon Clay Gift Fellowship to pursue Post-doctoral Research at Whitehead Institute for Biomedical Research (MIT) Cambridge, MA USA June 2010-2012.
Trainee Abstract Travel Award to attend Annual meeting of American Association of Immunologist held at Seattle, WA USA May 2009.
Awardee of ‘Excellence in Graduate Student’ category in 2nd Annual Research Symposium of Comparative and Experimental Medicine held at The University of Tennessee, Knoxville TN. USA July 17, 2008
National Institute of Allergy and Infectious Disease (NIAID, NIH) Scholarship to attend Keystone Symposia on Viral immunity. Held at Keystone, Colorado, USA. Jan 2008.
National Institute of Allergy and Infectious Disease (NIAID, NIH) Scholarship to attend Keystone Symposia on Tolerance in Transplantation and Autoimmunity. Held at Keystone, Colorado, USA Feb 2008.
Passed National Eligibility Test conducted by CSIR/UGC, India
Merit stipend during Master’s degree programme at CCS Haryana Agricultural Univeristy, Hisar India
Merit Scholarship during Bachelor of Veterinary Science and Animal Husbandry at CCS Haryana Agricultural University, Hisar, India
Sidhanta Nanda, Mohammad Adeel Zafar, Taruna Lamba, Jonaid Ahmad Malik, Mohammad Affan Khan, Priya Bhardwaj, Bhawana Bisht, Rohan Ghadi, Gurpreet Kaur, Vijayender Bhalla and others. A novel strategy to elicit enduring anti-morphine immunity and relief from addiction by targeting Acr1 protein nano vaccine through TLR-2 to dendritic cells. International Journal of Biological Macromolecules, page 133188, 2024. Roman Sarkar, Mohammad Shaaz and Sharvan Sehrawat. Myeloid derived suppressor cells potentiate virus-specific memory CD8+ T cell response. Microbes and Infection 26(3):105277, 2024. Juhi Jain, Yash Chaudhary, Sharad Kumar Gaur, Prabhakar Tembhurne, Shanmugam Chandra Sekar, Muthuchelvan Dhanavelu, Sharvan Sehrawat and Rajeev Kaul. Peste des petits ruminants virus non-structural V and C proteins interact with the NF-$\kappa$B p65 subunit and modulate pro-inflammatory cytokine gene induction. Journal of General Virology 104(10):001907, 2023. Jonaid Ahmad Malik, Sidhanta Nanda, Mohammad Adeel Zafar, Sharvan Sehrawat and Javed N Agrewala. Influence of chronic administration of morphine and its withdrawal on the behaviour of zebrafish. Journal of Biosciences 48(3):33, 2023. Yash Chaudhary, Juhi Jain, Sharad Kumar Gaur, Prabhakar Tembhurne, Shanmugam Chandrasekar, Muthuchelvan Dhanavelu, Sharvan Sehrawat and Rajeev Kaul. Nucleocapsid Protein (N) of Peste des petits ruminants Virus (PPRV) Interacts with Cellular Phosphatidylinositol-3-Kinase (PI3K) Complex-I and Induces Autophagy. Viruses 15(9):1805, 2023. Sachin Mulik, Engin Berber, Sharvan Sehrawat and Barry Tyrrell Rouse. Controlling viral inflammatory lesions by rebalancing immune response patterns. Frontiers in Immunology 14:1257192, 2023. Surbhi Dahiya, Sudhakar Singh and Sharvan Sehrawat. Protocol for investigating the biogenesis of SARS-CoV-2 S pseudoviruses in HEK293T cells transduced to express the virus-specific intrabodies. STAR protocols 4(1):101977, 2023. Sharvan Sehrawat, Nikolaus Osterrieder, Scott D Schmid and Barry T Rouse. Can the triumph of mRNA vaccines against COVID-19 be extended to other viral infections of humans and domesticated animals?. Microbes and infection 25(1-2):105078, 2023. Sharvan Sehrawat. Toxicity screening and ranking of diverse engineered nanomaterials using established hierarchical testing approaches with a complementary in vivo zebrafish model.. , 2022. Sharvan Sehrawat. Targeting dendritic cells with TLR-2 ligand–coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity. , 2022. S Nadeem, S Nanda, MA Zafar, P Singh, S Singh, SK Maurya, H Bashir, S Sehrawat, DK Das, V Bhalla and others. Targeting dendritic cells with TLR-2 ligand–coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity. , 2022. Deepjyoti Kumar Das, Mohammad Adeel Zafar, Sidhanta Nanda, Sanpreet Singh, Taruna Lamba, Hilal Bashir, Pargat Singh, Sudeep Kumar Maurya, Sajid Nadeem, Sharvan Sehrawat and others. Targeting dendritic cells with TLR-2 ligand–coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity. Journal of Biological Chemistry 298(12), 2022. Azeez Tehseen, Dhaneshwar Kumar, Roman Sarkar, Sudhakar Singh, Abhishek Dubey and Sharvan Sehrawat. Glucocorticoid signaling mediates CD8+ T cell memory differentiation. bioRxiv, pages 2022–07, 2022. Sudhakar Singh, Surbhi Dahiya, Yuviana J Singh, Komal Beeton, Ayush Jain, Roman Sarkar, Abhishek Dubey, Azeez Tehseen and Sharvan Sehrawat. Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses. Iscience 25(7), 2022. Jasreen Kaur, Ikjot Singh Sohal, Harpreet Singh, Naveen Kumar Gupta, Sharvan Sehrawat, Sanjeev Puri, Dhimiter Bello and Madhu Khatri. Toxicity screening and ranking of diverse engineered nanomaterials using established hierarchical testing approaches with a complementary in vivo zebrafish model. Environmental Science: Nano 9(8):2726–2749, 2022. Roman Sarkar, Yashu Sharma, Ayush Jain, Azeez Tehseen, Sudhakar Singh and Sharvan Sehrawat. A Combinatorial in-silico, in-vitro and in-vivo Approach to Quantitatively Study Peptide Induced MHC Stability. Bio-protocol 11(24):e4255–e4255, 2021. Ayush Jain. Attempt at elucidating the role of Galectin-3 in CD8T cell biology during viral infection using nanobodies. IISERM, 2021. Chahat Badhan and S Sehrawat. Myeloid derived suppressor cells and hsv-1 latency. IISERM, 2021. Sahil Threja. Role of interferons in maintaining the integrity of Blood brain barrier during PPRV infection. IISERM, 2021. Yashu Sharma, Roman Sarkar, Ayush Jain, Sudhakar Singh, Chander Shekhar, Chandrasekar Shanmugam, Muthuchelvan Dhanavelu, Prabhakar Tembhurne, Rajeev Kaul and Sharvan Sehrawat. A mouse model of PPRV infection for elucidating protective and pathological roles of immune cells. Frontiers in Immunology 12:630307, 2021. Sudhakar Singh, Surbhi Dahiya, Yuviana J Singh, Komal Beeton, Ayush Jain, Roman Sarkar, Abhishek Dubey, Syed Azeez Tehseen and Sharvan Sehrawat. Targeting conserved viral virulence determinants by single domain antibodies to block SARS-CoV2 infectivity. bioRxiv, pages 2021–01, 2021. Sharvan Sehrawat and Barry T Rouse. COVID-19: disease, or no disease?-that is the question. It’s the dose stupid!. Microbes and Infection 23(1):104779, 2021. Abhishek Dubey, Surbhi Dahiya, Barry T Rouse and Sharvan Sehrawat. Reducing SARS-cov2 infectivity and its associated immunopathology.. , 2020. Preeti P Bramhapurkar, Prabhakar A Tembhurne, Chandra S Sekar, D Muthucheven, Sharvan Sehrawat, Prashant Tarale, Vijay C Ingle and Rajeev Kaul. Circulating MicroRNA-21-3p: A Potential Biomarker for Peste-des petits ruminants Virus in Naturally Infected Goats. Int. J. Curr. Microbiol. App. Sci 9(8):341–351, 2020. Yashu Sharma, Roman Sarkar, Ayush Jain, Sudhakar Singh, Chander Shekhar, ChandraSekar Shanmugam, Muthuchelvan Dhanavelu, Prabhakar Tembure, Rajeev Kaul and Sharvan Sehrawat. Modeling PPRV pathogenesis in mice to assess the contribution of innate cells and anti-viral T cells. bioRxiv, pages 2020–10, 2020. Abhishek Dubey, Surbhi Dahiya, Barry T Rouse and Sharvan Sehrawat. Perspective: Reducing SARS-CoV2 infectivity and its associated immunopathology. Frontiers in Immunology 11:581076, 2020. Sharvan Sehrawat and Barry T Rouse. Does the hygiene hypothesis apply to COVID-19 susceptibility?. 2020. Roman Sarkar and Sharvan Sehrawat. Role of myeloid derived suppressor cells in regulating herpes stromal keratitis. The Journal of Immunology 204(1_Supplement):144–8, 2020. Sharvan Sehrawat and Manpreet Kaur. Galectin-3 as a modifier of anti-microbial immunity: unraveling the unknowns. Glycobiology 30(7):418–426, 2020. Aswathy Joji. SELECTION AND CHARACTERISATION OF PPRV-SPECIFIC SINGLE DOMAIN ANTIBODIES. IISERM, 2019. Manpreet Kaur, Abhishek Dubey, Madhu Khatri and Sharvan Sehrawat. Secretory PLA2 specific single domain antibody neutralizes Russell viper venom induced cellular and organismal toxicity. Toxicon 172:15–18, 2019. Roman Sarkar, Amal Mathew and Sharvan Sehrawat. Myeloid-derived suppressor cells confer infectious tolerance to dampen virus-induced tissue immunoinflammation. The Journal of Immunology 203(5):1325–1337, 2019. Dhaneshwar Kumar and Sharvan Sehrawat. Divergent effects of a transient corticosteroid therapy on virus-specific quiescent and effector CD8+ T cells. Frontiers in Immunology 10:1521, 2019. Manpreet Kaur, Madhu Khatri and Sharvan Sehrawat. Synthesis and Production of Different Biomolecules for Application in the Sensing of Environmental Pollutants. In Advances in Nanosensors for Biological and Environmental Analysis. Elsevier, 2019, pages 63–77. Manpreet Kaur, Dhaneshwar Kumar, Vincent Butty, Sudhakar Singh, Alexandre Esteban, Gerald R Fink, Hidde L Ploegh and Sharvan Sehrawat. Galectin-3 regulates $\gamma$-herpesvirus specific CD8 T cell immunity. IScience 9:101–119, 2018. Sharvan Sehrawat and Rajeev Kaul. Veterinarians as scientific contributors in mainstream biomedical research. Current Science 115(4):616–617, 2018. Sharvan Sehrawat, Dhaneshwar Kumar and Barry T Rouse. Herpesviruses: harmonious pathogens but relevant cofactors in other diseases?. Frontiers in cellular and infection microbiology 8:177, 2018. Sharvan Sehrawat and Barry T Rouse. Immunity to infections. eLS, pages 1–12, 2017. Sharvan Sehrawat and Barry T Rouse. Interplay of regulatory T cell and Th17 cells during infectious diseases in humans and animals. Frontiers in immunology 8:341, 2017. S Sehrawat. An Approach to Control Relapse of Inflammatory Lesions after Discontinuation of Primary Therapy. , 2014. Pradeep BJ Reddy, Sharvan Sehrawat, Amol Suryawanshi, Naveen K Rajasagi, Madhu Khatri and Barry T Rouse. An approach to control relapse of inflammatory lesions after discontinuation of primary therapy. Plos one 9(5):e98051, 2014. Tamara Veiga-Parga, Sharvan Sehrawat and Barry T Rouse. Role of regulatory T cells during virus infection. Immunological reviews 255(1):182–196, 2013. Lee Kim Swee, Carla P Guimaraes, Sharvan Sehrawat, Eric Spooner, Inmaculada M Barrasa and Hidde L Ploegh. Sortase-mediated modification of $\alpha$DEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes. Proceedings of the National Academy of Sciences 110(4):1428–1433, 2013. Sharvan Sehrawat, Paul-Albert Koenig, Oktay Kirak, Christian Schlieker, Manuel Fankhauser and Hidde L Ploegh. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood, The Journal of the American Society of Hematology 121(7):1145–1156, 2013. Sharvan Sehrawat, Pradeep Reddy, Amol Suryawanshi, Madhu Khatri and Barry Rouse. Th17 mediated recurrence of virus-induced immunopathology following discontinued FTY720 treatment (105.10). The Journal of Immunology 188(1_Supplement):105–10, 2012. Alexander Pichugin, Lindsey Ehrler, Sharvan Sehrawat, Theresa Funk, Cate Speake, Patrick Duffy, Hidde Ploegh and Urszula Krzych. Identification of Plasmodium berghei novel liver stage CD8 T cell epitopes by caged MHC class I tetramer technology (43.30). The Journal of Immunology 188(1_Supplement):43–30, 2012. Sharvan Sehrawat, Oktay Kirak, Paul-Albert Koenig, Marisa K Isaacson, Sofia Marques, Gunes Bozkurt, Pedro J Simas, Rudolph Jaenisch and Hidde L Ploegh. CD8+ T cells from mice transnuclear for a TCR that recognizes a single H-2Kb-restricted MHV68 epitope derived from gB-ORF8 help control infection. Cell Reports 1(5):461–471, 2012. Naveen K Rajasagi, Amol Suryawanshi, Sharvan Sehrawat, Pradeep BJ Reddy, Sachin Mulik, Mitsuomi Hirashima and Barry T Rouse. Galectin-1 reduces the severity of herpes simplex virus-induced ocular immunopathological lesions. The Journal of Immunology 188(9):4631–4643, 2012. Barry T Rouse, Naveen K Rajasagi, Sachin Mulik, Mitsuomi Hirashima, Pradeep BJ Reddy, Sharvan Sehrawat and Amol Suryawanshi. Influence of Galectin-9/Tim-3 Interaction on. , 2011. Pradeep Babu Jagadeesh Reddy, Sharvan Sehrawat, Amol Suryawanshi, Naveen Rajasagi and Barry Rouse. An influence of galectin-9/Tim-3 interaction on Herpes simplex virus-1 latency (105.14). The Journal of Immunology 186(1_Supplement):105–14, 2011. BJ Reddy, Sharvan Sehrawat and Barry T Rouse. Ocular Neovascularization Caused by Herpes. , 2011. Pradeep BJ Reddy, Sharvan Sehrawat, Amol Suryawanshi, Naveen K Rajasagi, Sachin Mulik, Mitsuomi Hirashima and Barry T Rouse. Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency. The Journal of Immunology 187(11):5745–5755, 2011. Sharvan Sehrawat and Barry T Rouse. Tregs and infections: on the potential value of modifying their function. Journal of leukocyte biology 90(6):1079–1087, 2011. Amol Suryawanshi, Tamara Veiga-Parga, Naveen K Rajasagi, Pradeep Babu Jagdeesh Reddy, Sharvan Sehrawat, Shalini Sharma and Barry T Rouse. Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology. The Journal of Immunology 187(4):1919–1930, 2011. Amol Suryawanshi, Sachin Mulik, Shalini Sharma, Pradeep BJ Reddy, Sharvan Sehrawat and Barry T Rouse. Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor. The Journal of Immunology 186(6):3653–3665, 2011. Yasmine Belkaid, Sharvan Sehrawat and Barry T Rouse. Regulation of antimicrobial immunity. The Immune Response to Infection, pages 109–120, 2010. Sharvan Sehrawat, Mitsuomi Hirashima and Barry Rouse. Regulation of virus-specific acute and memory CD8+ T cell response by Galectin-9/TIM-3 interaction (137.5). The Journal of Immunology 184(1_Supplement):137–5, 2010. Sharvan Sehrawat, Pradeep BJ Reddy, Naveen Rajasagi, Amol Suryawanshi, Mitsuomi Hirashima and Barry T Rouse. Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8+ T cell response. PLoS pathogens 6(5):e1000882, 2010. Barry T Rouse and Sharvan Sehrawat. Immunity and immunopathology to viruses: what decides the outcome?. Nature Reviews Immunology 10(7):514–526, 2010. Sharvan Sehrawat, Mitsuomi Hirashima and Barry T Rouse. Differential effects of galectin-9 ligation with TIM-3 expressed on Th1 and Tregs (89.12). The Journal of Immunology 182(1_Supplement):89–12, 2009. Sharvan Sehrawat, Amol Suryawanshi, Mitsuomi Hirashima and Barry T Rouse. Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. The Journal of Immunology 182(5):3191–3201, 2009. Sharvan Sehrawat. Regulation of Herpetic Stromal Keratitis: Role of Regulatory T Cells. , 2008. Sharvan Sehrawat, Susmit Suvas, Pranita P Sarangi, Amol Suryawanshi and Barry T Rouse. In vitro-generated antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of herpes simplex virus-induced ocular immunoinflammatory lesions. Journal of virology 82(14):6838–6851, 2008. Pranita P Sarangi, Sharvan Sehrawat, Susmit Suvas and Barry T Rouse. IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology. The Journal of Immunology 180(9):6297–6306, 2008. Sharvan Sehrawat and Barry T Rouse. Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators. The Journal of Immunology 180(11):7636–7647, 2008. Susmit Suvas, Barry T Rouse and others. In vitro generated antigen specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of virus induced immunoinflammatory lesion (99.3). The Journal of Immunology 178(1_Supplement):S194–S194, 2007. Sharvan Sehrawat, Susmit Suvas and Barry T Rouse. In vitro generated antigen specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of virus induced immunoinflammatory lesion (99.3). The Journal of Immunology 178(1_Supplement):S194–S194, 2007. Susmit Suvas, Hye Mee Joo, Sharvan Sehrawat, Pratima Krishna Suvas, Mark Y Sangster, Hideo Yagita, Miyuki Azuma and Barry T Rouse. Functional significance of PD-1 expression on aging T cells (85.4). The Journal of Immunology 178(1_Supplement):S118–S118, 2007. Pranita Pragnyadipta Sarangi, Susmit Suvas, Sharvan Sehrawat, Bumseok Kim and Barry T Rouse. IL-10 and natural regulatory T cells: two independent anti inflammatory mechanisms in HSV induced ocular immonopathology (B63). The Journal of Immunology 178(1_Supplement):LB13–LB13, 2007. Barry T Rouse and Sharvan Sehrawat. Regulatory T cells and infectious disease. Immune Network 7(4):167–172, 2007. S Sehrawat and A Singh. Anti-erythrocyte natural antibody activity in the unconventional ‘heavy chain’immunoglobulins of Indian desert camel (Camelus dromedarius). Veterinary immunology and immunopathology 111(3-4):139–147, 2006. Sharvan Sehrawat. Study on Heavy Chain Antibodies of Indian Desert Camel (Camel; us Dromedarius) with Particular Reference to Their Natural Antibody Activity. Veterinary Immunology, CCSHAU, Hisar, 2004. Sharvan Sehrawat and Ajit Singh. Physico-chemical and antigenic characterization of unconventional heavy chain antibodies of Indian desert camel (Camelus dromedarius L.). , 2004.