Professor
Department of Biological Sciences
📍 3F5, AB2
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Research Area
Molecular & Cellular Biophysics; Chemical & Synthetic Biology
Research Interests
Intrinsically Disordered Proteins; Biological Condensates; Macromolecular Phase Separation; Membrane-less Organelles; Prions; Amyloids; Fluorescence & Raman Spectroscopy and Microscopy; Single-Molecule Biophysics; Super-resolution and Nanoscale Imaging
Since 2020 : Professor, IISER Mohali
2013 - 2020 : Associate Professor, IISER Mohali
2008 - 2013 : Assistant Professor, IISER Mohali
2005 - 2008 : Postdoctoral Research Associate, The Scripps Research Institute, La Jolla, California, USA
2004 - 2005 : Visiting Fellow, Tata Institute of Fundamental Research (TIFR), Mumbai
2000 - 2004 : PhD. Indian Institute of Science (IISc), Bangalore
1997 - 2000 : MS. Indian Institute of Science (IISc), Bangalore
1994 - 1997 : BSc. Jadavpur University, Kolkata (Calcutta)
Recipient of the JC Bose Fellowship.
Fellow, Indian National Science Academy (INSA), New Delhi (FNA).
Fellow, Indian Academy of Sciences, Bangalore (FASc).
Chair, Intrinsically Disordered Proteins subgroup of the Biophysical Society, USA.
Editorial Board Member, Biophysical Journal (Cell Press).
Sandeep K Rai, Roopali Khanna, Anamika Avni and Samrat Mukhopadhyay. Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates. Proceedings of the National Academy of Sciences 120(2), 2023. URL, DOI
Sayanta Mahapatra, Anusha Sarbahi, Neha Punia, Ashish Joshi, Anamika Avni, Anuja Walimbe and Samrat Mukhopadhyay. ATP modulates self-perpetuating conformational conversion generating structurally distinct yeast prion amyloids that limit autocatalytic amplification. Journal of Biological Chemistry 299(5):104654, 2023. URL, DOI
Ashish Joshi, Anuja Walimbe, Anamika Avni, Sandeep K Rai, Lisha Arora, Snehasis Sarkar and Samrat Mukhopadhyay. Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation. Nature Communications 14(1), 2023. URL, DOI
Debapriya Das, Lisha Arora and Samrat Mukhopadhyay. Short-Range Backbone Dihedral Rotations Modulate Internal Friction in Intrinsically Disordered Proteins. Journal of the American Chemical Society 144(4):1739–1747, January 2022. URL, DOI
Aishwarya Agarwal, Sandeep K Rai, Anamika Avni and Samrat Mukhopadhyay. An intrinsically disordered pathological prion variant Y145Stop converts into self-seeding amyloids via liquid\textendashliquid phase separation. Proceedings of the National Academy of Sciences 118(45), November 2021. URL, DOI
Priyanka Dogra, Ashish Joshi, Anupa Majumdar and Samrat Mukhopadhyay. Intermolecular Charge-Transfer Modulates Liquid–Liquid Phase Separation and Liquid-to-Solid Maturation of an Intrinsically Disordered pH-Responsive Domain. Journal of the American Chemical Society 141(51):20380–20389, November 2019. URL, DOI
Anupa Majumdar, Priyanka Dogra, Shiny Maity and Samrat Mukhopadhyay. Liquid\textendashLiquid Phase Separation Is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules. The Journal of Physical Chemistry Letters 10(14):3929–3936, June 2019. URL, DOI