Professor
Department of Chemical Sciences
📍 5F12/AB2
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Research Area
Organic Synthesis and Catalysis
Research Interests
I. Organocatalysis with phosphines : We routinely pursue metal-free chemistry with nucleophilic trivalent organophosphines. Some key contributions to this area include the development of asymmetric intramolecular Morita-Baylis-Hillman reaction and its variants, phosphine-promoted reductive- and vinylogous aldol reactions, phosphine-catalyzed intramolecular hydroalkylation, and hydroacylation chemistry, etc.
II. Cascade transformations with sulphur ylides : Sulfur ylides are traditionally employed to synthesize cyclopropanes, epoxides, and aziridines from the respective olefins, carbonyls, and imines. We made a serendipitous entry into this field and articulated several one-pot cascade transformations employing sulfur ylides as reagents that provided facile access to unprecedented cyclopropanoids.
Since Oct 2023 : Head, Department of Chemical Sciences, IIISER Mohali, India
Since Dec 2023 : Professor, Department of Chemical Sciences, IISER Mohali, India
2017 - 2023 : Associate Professor, Department of Chemical Sciences, IISER Mohali, India
2011 - 2017 : Assistant Professor, Department of Chemical Sciences, IISER Mohali, India
2010 - 2011 : Senior Research Scientist, Jubilant Biosys Ltd., Bangalore, India
2008 - 2010 : Senior Research Investigator, Bristol-Myers Squibb Biocon Research Center (BBRC) Syngene International Ltd., Bangalore, India
2005 - 2008 : Postdoctoral fellow, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. Carlos F. Barbas, III)
2001 - 2005 : Ph.D., Indian Institute of Science, Bangalore, India (Advisor: Prof. A. Srikrishna)
1999 - 2001 : M.Sc. (Organic Chemistry), Andhra University, Visakhapatnam, India
1996 - 1999 : B.Sc. (Chemistry), Andhra University, Visakhapatnam, India
Received International Travel Support from SERB and Travel Award from ACS-DOC to participate in the ACS Spring Meeting 2024 in New Orleans, USA
Council member of the 'National Organic Symposium Trust (NOST)' for the period 2023-26
Invited to become the 'Fellow of the Royal Society of Chemistry (FRSC)' under 'Leaders in the Field (LITF)' scheme (2022)
Recipient of the CDRI Award for Excellence in Drug Research 2022
Editorial Board member of Organic & Biomolecular Chemistry from February 2022
Awarded the 'RSC Research Fund' grant 2020
Swarnajayanti Fellowship (2017-18) awarded by the Department of Science & Technology (DST), Govt. of India
A. V. Rama Rao Research Foundation (AVRA) Young Scientist Award 2018
Outstanding Reviewer for Organic & Biomolecular Chemistry (2018), The Journal of Chemical Sciences (2022)
Organisation of Pharmaceutical Producers of India (OPPI) Young Scientist award 2018
Chemical Research Society of India (CRSI) Bronze Medal 2018
Editorial Advisory Board member of Organic & Biomolecular Chemistry during 2017-2022
Thieme Chemistry Journals Award 2017
Young Scientist award from the organizing committee of 'Chemical Frontiers Goa' in 2016
Admitted as a Member of the Royal Society of Chemistry (MRSC) in 2016
Skaggs Postdoctoral Fellowship, The Scripps Research Institute, La Jolla, USA [2005-08]
Bara Singh, Shivam K Pandey, Nirmal Malik and SSV Ramasastry. Morita–Baylis–Hillman Spirannulation under Phosphine-and Anion-Binding Catalysis. Organic Letters 26(15):3273–3278, 2024.
Jay Prakash Maurya and SSV Ramasastry. Phosphine-Promoted Ring Opening/Recyclization of Cyclopropyl Ketones to Access Hydrofluorenones. Organic Letters 26(11):2282–2286, 2024.
Bara Singh, Arshad J Ansari, Nirmal Malik and SSV Ramasastry. An interrupted Corey–Chaykovsky reaction of designed azaarenium salts: synthesis of complex polycyclic spiro-and fused cyclopropanoids. Chemical Science 14(25):6963–6969, 2023.
Prashant Kumar, Pravesh Kumar, Sugumar Venkataramani and SSV Ramasastry. Pd-Catalyzed formal [3+ 3] heteroannulation of allylic gem-diacetates: synthesis of chromene-based natural products and exploration of photochromic properties. ACS Catalysis 12(2):963–970, 2021.
Bara Singh, Siddheshwar K Bankar, Ketan Kumar and SSV Ramasastry. Palladium-catalysed 5-endo-trig allylic (hetero) arylation. Chemical Science 11(19):4948–4953, 2020.
Atanu Mondal, Raju Hazra, Jagdeep Grover, Moluguri Raghu and SSV Ramasastry. Organophosphine-catalyzed intramolecular hydroacylation of activated alkynes. ACS Catalysis 8(4):2748–2753, 2018.
Siddheshwar K Bankar, Bara Singh, Pinku Tung and SSV Ramasastry. Palladium-Catalyzed Intramolecular Trost–Oppolzer-Type Alder–Ene Reaction of Dienyl Acetates to Cyclopentadienes. Angewandte Chemie International Edition 57(6):1678–1682, 2018.
Seema Dhiman, Uttam K Mishra and SSV Ramasastry. One-Pot Trimetallic Relay Catalysis: A Unified Approach for the Synthesis of $\beta$-Carbolines and Other [c]-Fused Pyridines. Angewandte Chemie 128(27):7868–7872, 2016.
Bishnupada Satpathi and SSV Ramasastry. Morita–Baylis–Hillman reaction of $\beta$, $\beta$-disubstituted enones: an enantioselective organocatalytic approach for the synthesis of cyclopenta [b] annulated arenes and heteroarenes. Angewandte Chemie International Edition 55(5):1777–1781, 2016.