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Accelerating Biologics Design Through Computational Modeling
Wednesday 16 July 2025, 10:30am
Dr. Koushik Kasavajhala, Senior Scientist at Schrödinger
Location : AB2-5A
About the speaker: Koushik Kasavajhala is a Senior Scientist at Schrödinger. He has a Ph.D. in Chemistry (2020) from Stony Brook University.
About the talk:Rational design of biologics such as antibodies, and engineered proteins, presents a significant challenge due to the complex interplay of multiple parameters such as stability, binding affinity, selectivity, immunogenicity etc. Each mutation can differentially influence these properties, making the development of biologics a high-dimensional, multi-objective, problem in optimization.
In this seminar, we will highlight advanced computational approaches, integrating physics-based simulations to systematically accelerate and streamline the biologics design process.
Particular emphasis will be given to strategies for predicting and enhancing protein stability and binding affinity, which are both critical determinants of therapeutic efficacy and developability.
About the talk:Rational design of biologics such as antibodies, and engineered proteins, presents a significant challenge due to the complex interplay of multiple parameters such as stability, binding affinity, selectivity, immunogenicity etc. Each mutation can differentially influence these properties, making the development of biologics a high-dimensional, multi-objective, problem in optimization.
In this seminar, we will highlight advanced computational approaches, integrating physics-based simulations to systematically accelerate and streamline the biologics design process.
Particular emphasis will be given to strategies for predicting and enhancing protein stability and binding affinity, which are both critical determinants of therapeutic efficacy and developability.
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