IISER MOHALI

Abstract: Tissue morphogenesis is a complex, highly regulated process orchestrated by distinct cell- and tissue-specific signaling networks. While significant progress has been made in understanding genetic and transcriptional factors, a comprehensive analysis of the proteomic landscape governing morphogenesis is essential for a deeper mechanistic understanding. Here, we present a proteomics-based approach to identify and characterize the key regulatory proteins and pathways that drive tissue-specific morphogenetic events. Using advanced mass spectrometry and bioinformatics, we map protein expression profiles, post-translational modifications and protein- protein interactions within developing tissues and individual cell types. This approach allows the dissection of specific regulatory networks and provides new insights into the spatial and temporal control of protein function during tissue development.