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Discovery of a Novel Drug Candidate Targeting the Membrane (M) Protein of Coronaviruses: Role of AI in Accelerating Drug Discovery
Monday 26 May 2025, 04:00pm
Prof. Koul, Vice President and Head of Global Public Health Discovery & Partnerships at Johnson & Johnson
Location : LH3 (LHC)
Talk summary
This talk will present the latest research on the discovery of a preclinical drug targeting a major structural component of the viral envelope—the Membrane (M) protein. The compound, JNJ-9676, demonstrated excellent efficacy in animal models. The M protein plays a critical role in the formation and assembly of infectious virus particles. JNJ-9676 locks the M protein in a non-functional state, thereby preventing viral replication. Notably, the drug is active against emerging strains of beta-coronaviruses isolated from bats and pangolins, underscoring its potential both in the treatment of COVID-19 and in broader pandemic prevention efforts. Furthermore, Artificial intelligence played a pivotal role in accelerating the identification and optimization of this promising candidate in a record time.
This talk will present the latest research on the discovery of a preclinical drug targeting a major structural component of the viral envelope—the Membrane (M) protein. The compound, JNJ-9676, demonstrated excellent efficacy in animal models. The M protein plays a critical role in the formation and assembly of infectious virus particles. JNJ-9676 locks the M protein in a non-functional state, thereby preventing viral replication. Notably, the drug is active against emerging strains of beta-coronaviruses isolated from bats and pangolins, underscoring its potential both in the treatment of COVID-19 and in broader pandemic prevention efforts. Furthermore, Artificial intelligence played a pivotal role in accelerating the identification and optimization of this promising candidate in a record time.
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