IISER MOHALI

We give an overview of and our contribution towards a major non-ionizing alternative to current gold-standard nuclear medicine modalities for physiological(functional) imaging for early cancer detection and metabolic imaging, such as static and dynamic(pharmacokinetic) PET; namely, optical fluorescence and photoacoustic based pharmacokinetic tomography.

In the current talk, we motivate and present solutions to the problem of obtaining time-varying concentrations and pharmacokinetic rates of transfer of an injected fluorophore between the plasma, extra-cellular extra-vascular and elimination compartments in a tissue model. We review the fully non-linear dynamic pharmacokinetic fluorescence photoacoustic tomography (PK-FPAT) frameworks for shape-based and pointwise reconstructions for this upcoming modality in biomedical imaging.