Former Director (Sep 2017 - Feb 2019)
Professor
Department of Biological Sciences
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Research Area
Biochemistry, Molecular Virology, Cell Biology, Immunology, Biotechnology, Model Membranes and Drug/Gene Targeting.
Research Interests
Research in Molecular Virology, and Drug/Gene Targeting.
J.C. BOSE National Fellowship (DST) Award (2010-)
Elected Fellow of the Indian National Science Academy (INSA), New Delhi, 2010.
Elected, Fellow of The Indian Academy of Sciences (2007).
M. Sreenivasaya Memorial Award, by SBC, India, 2005.
Shanti Swarup Bhatnagar Prize in Biological Sciences, 1998.
Elected, Fellow of The National Academy of Sciences, India (1996).
Society of Biological Chemists, Life Member, 1995 (India).
Guha Research Conference (India, Elected, 1994).
Selected Patents:
Sarkar, Debi P. Ramani, Komal, Bora, Roop S., Kumar, Mukesh, and Tyagi, Sandeep K. Process for Producing A Targeted Gene. US Patent Application Granted. Patent No. 5,683,866; Date. 4th Nov, 1997.
Debi P. Sarkar et. al. (2005) “Process for producing modified reconstituted Sendai viral envelope specific for drug and/or gene delivery to liver cells” Indian Patent Applications Filed. #1003/Del/2005 dated 21/4/2005. PCT application filed, October, 2005 (PCT No. PCT/IN2006/000061 dated 6th Nov., 2009). USA Patent Application Published, Pub. No. US 2010/0047897 A1, dated 25th Feb., 2010, Accepted/Published other countries March, 2011.
Selected Publications:
Induction of Transcriptional Gene Silencing by Expression of shRNA Directed to c-Myc P2 Promoter in Hepatocellular Carcinoma by Tissue-Specific Virosomal Delivery. Mohammad Khalid Zakaria, Debi P. Sarkar and Parthaprasad Chattopadhyay. Methods Mol Biol. 2017; 1543:245-257. IF:1.2
Imran Khan, Mohammad Khalid Zakaria, Mukesh Kumar, Prashant Mani, Parthaprasad Chattopadhyay, Debi P. Sarkar and Subrata Sinha. A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment based virosomal delivery for neoplastic cell targeting. Journal of Translational Medicine 13, 254; DOI 10.1186/s/12967-015-0602-1 (Published on line 5th August, 2015) IF:3.93
Provas Das, Shekhar Saha, Sunandini Chandra, Alakesh Das, Sumit K. Dey, MahuaR Das, Shamik Sen, Debi P Sarkar and Siddhartha S Jana. Phosphorylation of Nonmuscle myosin II-A regulatory light chain resists Sendai virus fusion with host cells. Scientific Reports (Nature Group), 5, 10395; doi:10.038/srep 10395 (2015) IF:5.578
Mukesh Kumar, Prashant Mani, Pooja Pratheesh, Sunandini Chandra, Meghala Jeyakkodi, Parthaprasad Chattopadhyay , Debi P. Sarkar and Subrata Sinha. Membrane fusion mediated targeted cytosolic drug delivery through scFv engineered Sendai viral envelopes. Current Molecular Medicine , 15:1-15, 2015 IF:3.621
Zakaria Khalid Mohammad, Khan Imran, Mani Prashant, Chattopadhyay Parthaprasad, Sarkar P Debi, Sinha Subrata. Hepatocellular Carcinoma Specific Transcriptional Interference of c-Myc promoter by alpha-fetoprotein and Sendai Virosome Based dsRNA System. The FASEB Journal, vol. 29 no. 1 Supplement, April 2015. IF:5.043
Zakaria Khalid Mohammad, Khan Imran, Mani Prashant, Sarkar P Debi, Chattopadhyay Parthaprasad, Sinha Subrata. Epigenetic repression of c-Myc P2 promoter by Sendai F-virosome mediated delivery of tumor specific shRNA in Hepatoma cells. Molecular Biology of Cell, vol. 25 no. 25, 3987, Dec 15 2014. IF:4.466
Zakaria Khalid Mohammad, Khan Imran, Mani Prashant, Chattopadhyay Parthaprasad, Sarkar P Debi, Sinha Subrata. Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells. BMC Cancer, 14:582, 2014. IF:3.362
Prasanna Bhat, Sivakumar Vadivel Gnanasundram, Prashant Mani, Debi P Sarkar and Saumitra Das. Targeting ribosome assembly on the HCV RNA using a small RNA molecule. RNA Biology, 9, 1-10, 2012 IF: 5.5