Assistant Professor
Department of Biological Sciences
📍 3F2- Academic Block II
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Research Area
Cellular stress biology, metabolism, aging
Research Interests
Our laboratory focuses on two broad research areas:
(i) Characterization of signal transduction mechanisms of novel cellular stress responses. We recently unraveled the physiological effects of thiol reductive stress. Thiol antioxidants disrupt the oxidative protein folding environment in the endoplasmic reticulum (ER), resulting in protein misfolding and ER stress. Using genetic screens in the nematode Caenorhabditis elegans, we discovered that thiol reductive stress activates the HIF-1-mediated hypoxia response pathway.
(ii) Effects of microbiota on host stress responses, metabolism, and lifespan. We are involved in identifying microbial components that modulate host metabolism and stress responses in ways that lead to increased lifespan.
2020 - 2020 : Assistant Professor, Indian Institute of Science Education and Research Bhopal, India
2017 - 2019 : Postdoctoral Scholar, Oregon Health & Science University, Portland OR USA
2015 - 2017 : Postdoctoral Associate - Duke University, Durham, NC, USA
2010 - 2015 : PhD, National Centre for Biological Sciences, TIFR, Bengaluru, India
2008 - 2010 : MSc (Biotechnology & Molecular Biology), CCS Haryana Agricultural University, Hisar, Haryana, India
2005 - 2008 : BSc (Biology & Chemistry), S.D. College, Panipat, KU Kurukshetra, Haryana, India
Young Associate of the Indian National Science Academy - 2024
Associate of the Indian Academy of Sciences - 2023
Har Gobind Khorana-Innovative Young Biotechnologist Fellowship from the Department of Biotechnology, India - 2023
Ramalingaswami Re-entry Fellowship from the Department of Biotechnology, India - 2023
Rittenberg Meritorious Research Travel Award from the Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, USA - 2019
Mitchell Meritorious Research Travel Award from the Center for Host-Microbial Interactions, Duke University, Durham, USA - 2017
TIFR Alumni Association – Zita Lobo Memorial Award for the best PhD thesis in Biological and Chemical Sciences - 2016
Professor Obaid Siddiqi Best Paper Award 2014 from the National Centre for Biological Sciences, Bengaluru, India - 2015
Best poster award at NCBS annual meeting - 2015
First prize in M.Sc. for academic performance (2008-2010) from CCS Haryana Agricultural University, Hisar, Haryana, India - 2012
Qualified CSIR-JRF, ICMR-JRF, DBT-JRF, and GATE - 2010
Shivani Gahlot and Jogender Singh. Caenorhabditis elegans neuronal RNAi does not render other tissues refractory to RNAi. Proceedings of the National Academy of Sciences 121(22):e2401096121, 2024.
Rajneesh Rao, Alejandro Aballay and Jogender Singh. Inhibition of the UFD-1-NPL-4 complex triggers an inflammation-like response in Caenorhabditis elegans. eLife 13:RP94310, 2024.
Priyanka Das, Alejandro Aballay and Jogender Singh. Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling. eLife 12:RP89572, 2023.
Ravi, Ajay Kumar, Shalmoli Bhattacharyya and Jogender Singh. Thiol reductive stress activates the hypoxia response pathway. The EMBO Journal 42(22):e114093, 2023.
G Gokul and Jogender Singh. Dithiothreitol causes toxicity in C. elegans by modulating the methionine-homocysteine cycle. eLife 11:e76021, 2022.
Jogender Singh and Alejandro Aballay. Intestinal infection regulates behavior and learning via neuroendocrine signaling. eLife 8:e50033, 2019.
Jogender Singh and Alejandro Aballay. Microbial colonization activates an immune fight-and-flight response via neuroendocrine signaling. Developmental cell 49(1):89–99, 2019.
Jogender Singh and Jayant B Udgaonkar. Structural effects of multiple pathogenic mutations suggest a model for the initiation of misfolding of the prion protein. Angewandte Chemie International Edition 54(26):7529–7533, 2015.
Jogender Singh, Harish Kumar, Ambadi T Sabareesan and Jayant B Udgaonkar. Rational stabilization of helix 2 of the prion protein prevents its misfolding and oligomerization. Journal of the American Chemical Society 136(48):16704–7, 2014.