Assistant Professor
Department of Biological Sciences
📍 AB1 5F4
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Research Area
Epigenetic Mechanisms in Diabetic Vascular Complications
Research Interests
Diabetes and metabolic disorders significantly advance vascular complications such as cardiovascular disease, diabetic wound healing and retinopathy. Emerging evidence suggests that epigenetic factors and key long non-coding RNAs (lncRNAs) triggered by changing lifestyles and environment are new players in these pathologies. However, the epigenetic mechanisms involved and the role of lncRNAs in diabetes and its complications are still not well understood.
Das laboratory at IISER-Mohali, investigating the role of epigenetic regulators (enhancers/super-enhancers and lncRNAs) by utilizing state-of-the-art multi-omic approaches including single-cell transcriptomic and epigenomic analyses in VSMC and macrophage function, that are critical players in major diabetic vascular complications. We are also working on diabetes wound healing. Impaired wound healing due to diabetes can lead to chronic wounds and amputation of the foot. Macrophage dysfunction is an important feature of diabetic wound healing characterized by altered M1 and M2 populations (macrophage polarization). Although biochemical mechanisms involved in diabetic wound healing have been studied, contributing epigenetic mechanisms are not well known. We are investigating the functional roles of enhancers/SEs and lncRNAs in diabetic wound healing-associated gene expression and phenotypes in macrophages.
2023 - 2025 : Editorial Board Member of ATVB
2021 - 2022 : DBT/Wellcome Trust India Alliance Intermediate Fellow, CSIR-CDRI
2018 - 2020 : Staff Scientist, Beckman Research Institute of City of Hope, CA
2013 - 2018 : Postdoctoral Fellow, Beckman Research Institute of City of Hope, CA
2013 - 2013 : Postdoctoral Fellow, JNCASR, India
2008 - 2012 : Ph. D., Ecole Normale superieure de Lyon, FRANCE
2003 - 2005 : M.Sc. in Zoology, University of North Bengal, Siliguri, INDIA
1999 - 2002 : B.Sc. in Zoology, University of North Bengal, Siliguri, INDIA
Travel support to attend YIM-2024, Bhopal, India 2024
AcSIR Assistant Professor 2022-2023
Travel Grant to attend ASBMB 2018 meeting, City of Hope Postdoctoral Training Office, 2018
Travel Grant to attend ASBMB 2017 meeting, City of Hope Postdoctoral Training Office, 2017
Travel Grant to attend ASBMB 2017 meeting, ASBMB, 2017
4th year PhD fellowship, Fondation pour la Recherche Medicale (FRM), France, 2012
Travel Grant to attend Nucleosome 4D Conference. ENS Lyon, 2011
PhD fellowship, L’Ecole normale supèrieure de Lyon, France, 2008 for CEFIPRA project
PhD fellowship, University of North Bengal, India, 2007
Junior Research Fellowship, Council of Scientific and Industrial Research (CSIR), 2007
Graduate Aptitude Test in Engineering (GATE), 2006.
Ankita Priyadarshini, Riya Madan and Sadhan Das. Genetics and epigenetics of diabetes and its complications in India. Human Genetics 143(1):1–17, 2024.
Vinay Singh Tanwar, Marpadga A Reddy, Sadhan Das, Vishnu Amaram Samara, Maryam Abdollahi, Suchismita Dey, Vajir Malek, Rituparna Ganguly, Kenneth Stapleton, Linda Lanting and others. Palmitic acid–induced long noncoding RNA PARAIL regulates inflammation via interaction with RNA-binding protein ELAVL1 in monocytes and macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology 43(7):1157–1175, 2023.
Parijat Senapati, Aditya Bhattacharya, Sadhan Das, Suchismita Dey, Deepthi Sudarshan, Jyoti Vishwakarma, Surabhi Sudevan, Ravishankar Ramachandran, Tessy Thomas Maliekal and Tapas K Kundu. Histone chaperone Nucleophosmin regulates transcription of key genes involved in oral tumorigenesis. Molecular and Cellular Biology 42(2):e00669–20, 2022.
Marpadga A Reddy, Vishnu Amaram, Sadhan Das, Vinay Singh Tanwar, Rituparna Ganguly, Mei Wang, Linda Lanting, Lingxiao Zhang, Maryam Abdollahi, Zhuo Chen and others. lncRNA DRAIR is downregulated in diabetic monocytes and modulates the inflammatory phenotype via epigenetic mechanisms. JCI insight 6(11), 2021.
Sadhan Das, Marpadga A Reddy, Parijat Senapati, Kenneth Stapleton, Linda Lanting, Mei Wang, Vishnu Amaram, Rituparna Ganguly, Lingxiao Zhang, Sridevi Devaraj and others. Diabetes mellitus–induced long noncoding RNA Dnm3os regulates macrophage functions and inflammation via nuclear mechanisms. Arteriosclerosis, thrombosis, and vascular biology 38(8):1806–1820, 2018.
Parijat Senapati, Suchismita Dey, Deepthi Sudarshan, Sadhan Das, Manoj Kumar, Stephanie Kaypee, Azeem Mohiyuddin, Gopinath S Kodaganur and Tapas K Kundu. Oncogene c-fos and mutant R175H p53 regulate expression of Nucleophosmin implicating cancer manifestation. The FEBS journal 285(18):3503–3524, 2018.
Sadhan Das, Erli Zhang, Parijat Senapati, Vishnu Amaram, Marpadga A Reddy, Kenneth Stapleton, Amy Leung, Linda Lanting, Mei Wang, Zhuo Chen and others. A novel angiotensin II–induced long noncoding RNA giver regulates oxidative stress, inflammation, and proliferation in vascular smooth muscle cells. Circulation research 123(12):1298–1312, 2018.
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang and others. Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells. Nature communications 8(1):1467, 2017.
Sadhan Das, Rong Cong, Jayasha Shandilya, Parijat Senapati, Benoit Moindrot, Karine Monier, Hélène Delage, Fabien Mongelard, Sanjeev Kumar, Tapas K Kundu and others. Characterization of nucleolin K88 acetylation defines a new pool of nucleolin colocalizing with pre-mRNA splicing factors. FEBS letters 587(5):417–424, 2013.
Rong Cong, Sadhan Das, Iva Ugrinova, Sanjeev Kumar, Fabien Mongelard, Jiemin Wong and Philippe Bouvet. Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic acids research 40(19):9441–9454, 2012.