Assistant Professor
Department of Chemical Sciences
📍 1F9 (AB-1)
✉️
 |
 |
 |
 |
Research Area
Bioinspired Inorganic Chemistry
Research Interests
The basic theme of our research is to comprehend the yet unclear details pertaining to a number of crucial biological catalytic systems by utilizing suitable model compounds, and to interrogate how such comprehension may be sensibly applied to alleviate some of the paramount challenges we face today. Numerous examples exist where model systems have pioneered fruitful biochemical research in the absence of biological insights, exhibiting the remarkable potential of bioinspired model systems. Hence, we use the principles of synthetic organic, inorganic, and physical-inorganic chemistries to design new ligands and corresponding metal complexes that can provide as yet unknown reactivities, stabilize proposed intermediates, and address fundamental queries regarding structure-function relationships of various metalloenzymes. We use various spectroscopic methods (e.g. EPR, resonance Raman, Mössbauer, variable temperature UV-vis and NMR etc.) as part of our research program, and researchers will gain broad experience and achieve expertise across disciplines, with a foundation based upon inorganic chemistry, and extensions into organic and biological chemistries with industrial/medicinal/biotechnological application.
Since 2023 : Assistant Professor, IISER Mohali
2019 - 2023 : Postdoctoral Fellow, University of Alabama at Birmingham, USA
2018 - 2019 : Postdoctoral Fellow, University of Burgundy, France
2011 - 2017 : PhD, Indian Institute of Technology Kanpur
2009 - 2011 : M.Sc, Indian Institute of Technology Guwahati
2006 - 2009 : B.Sc, Jadavpur University, Kolkata
Dr. Congeniality Award from Office of Postdoctoral Education (2021 Postdoc Awards, September 23, 2021), University of Alabama at Birmingham, USA.
Awarded Postdoctoral fellowship “PARI II Santé” from Région Bourgogne France-Comté (December, 2017–December, 2018).
Awarded “International Travel Grant” by the Science and Engineering Research Board (SERB), India for attending 8th Asian Biological Inorganic Chemistry Conference (AsBIC 8), December 4–9, 2016 hosted by University of Auckland, New Zealand.
Awarded best poster award at 1st Research Scholar's Day (RSD-1) held at Department of Chemistry, I.I.T Kanpur on February 27, 2016.
Pritam Mondal, Dhilanka Udukalage, Abubaker A Mohamed, Henrik PH Wong, Sam P Visser and Gayan B Wijeratne. A Cytochrome P450 TxtE Model System with Mechanistic and Theoretical Evidence for a Heme Peroxynitrite Active Species. Angewandte Chemie, pages e202409430, 2024.
Pritam Mondal, Izumi Ishigami, Syun-Ru Yeh and Gayan B Wijeratne. The Role of Heme Peroxo Oxidants in the Rational Mechanistic Modeling of Nitric Oxide Synthase: Characterization of Key Intermediates and Elucidation of the Mechanism. Angewandte Chemie International Edition 61(48):e202211521, 2022.
Pritam Mondal, Shanuk Rajapakse and Gayan B Wijeratne. Following nature’s footprint: mimicking the high-valent heme-oxo mediated indole monooxygenation reaction landscape of heme enzymes. Journal of the American Chemical Society 144(9):3843–3854, 2022.
Pritam Mondal, Izumi Ishigami, Emilie F Gérard, Chaeeun Lim, Syun-Ru Yeh, Sam P Visser and Gayan B Wijeratne. Proton-coupled electron transfer reactivities of electronically divergent heme superoxide intermediates: a kinetic, thermodynamic, and theoretical study. Chemical Science 12(25):8872–8883, 2021.
Pritam Mondal and Sankar Prasad Rath. Cyclic metalloporphyrin dimers: Conformational flexibility, applications and future prospects. Coordination Chemistry Reviews 405:213117, 2020.
Pritam Mondal and Gayan B Wijeratne. Modeling tryptophan/indoleamine 2, 3-dioxygenase with heme superoxide mimics: is ferryl the key intermediate?. Journal of the American Chemical Society 142(4):1846–1856, 2019.