IISER MOHALI

Abstract: Sustainable energy inputs and modern catalysis are redefining how complex molecules are built. By harnessing visible light, electricity, and organocatalysis, we can access structurally diverse and stereochemically rich scaffolds from the same starting materials—often along entirely divergent pathways. These strategies reduce dependence on precious metals while providing exquisite control over chemo-, regio-, and stereoselectivity under mild conditions. By leveraging the complementary features of these activation modes, it is possible to channel the same substrate into distinct product classes simply by varying the energy input or the catalytic environment. In our laboratory, this principle is exemplified by the stereoselective divergent desymmetrization of cyclohexadienones,¹ the distinctive reactivity of styryl diazo compounds,² and the stereoselective construction of bridged biaryls.³ In each case, divergence and selectivity arises from the ability of different energy inputs to unlock unique reactivity patterns, which are then carefully harnessed and controlled through substrate design. By expanding the boundaries of what can be achieved with light, electricity, and organocatalysis, these approaches open new avenues for innovation in stereoselective synthesis. In this talk, I will present our recent efforts toward developing divergent stereoselective reactions enabled by these sustainable activation modes.

References:
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